ISSN 1941-5923



American Journal of Case Reports have been selected for the ESCI - Emerging Sources Citation Index (Thomson Reuters, Web of Science, ISI), launching in November of 2015 as a new edition of the Web of Science.

Clinical... read more

Published: 2015-12-01

Anti-Glomerular Basement Membrane Disease Combined with IgA Nephropathy Complicated with Reversible Posterior Leukoencephalopathy Syndrome: An Unusual Case

Ya-ting Ge, Jin-lan Liao, Wei Liang, Zu-ying Xiong

(Department of Nephrology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China (mainland))

Am J Case Rep 2015; 16:849-853

DOI: 10.12659/AJCR.894619

BACKGROUND: Anti-glomerular basement membrane disease (anti-GBM disease) is an autoimmune glomerulonephritis disease that is characterized by IgG linear deposition along the non-collagen domain of a3 chains of type IV collagen on the GBM. Although anti-GBM disease accompanied with IgA linear deposition along GBMs was discussed previously in some papers, anti-GBM disease combined with IgA granular deposition in the mesangial area, especially complicated with reversible posterior leukoencephalopathy syndrome (RPLS), was rarely reported. RPLS is usually caused by hypertensive encephalopathy, renal decompensation, fluid retention, and adverse effects of immunosuppressive drugs.
CASE REPORT: A male patient with the chief complaints of headache, gross hematuria, and nocturia was referred to our hospital. Based on renal biopsy, the diagnosis was finally confirmed as anti-GBM disease combined with IgA nephropathy and, the patient received comprehensive treatment, including cyclophosphamide (CTX), which led to symptom improvement. Two days after the third impulse CTX was given, he suddenly experienced headache and dizziness, which eventually developed into a tonic-clonic seizure. RPLS was identified by cranial magnetic resonance imaging (MRI) with reversible neuroimaging. After diazepam and antihypertension management, seizures were controlled. RPLS, a neurological complication, was found in anti-GBM disease with IgA nephropathy during our immunosuppressants therapy for the first time.
CONCLUSIONS: It is worth paying more attention to patients with rapidly progressive glomerulonephritis (RPGN), as they might be complicated with RPLS during intravenous administ... read more

Keywords: Anti-Glomerular Basement Membrane Disease, Glomerulonephritis, IGA, Posterior Leukoencephalopathy Syndrome

Published: 2015-11-30

Oral Spindle Cell Lipoma in a Rare Location: A Differential Diagnosis

Filipe Jaeger, Hermínia Marques Capistrano, Wagner Henriques de Castro, Patrícia Carlos Caldeira, Maria Auxiliadora Vieira do Carmo, Ricardo Alves de Mesquita, Maria Cássia Ferreira de Aguiar

Am J Case Rep 2015; 16:844-848

DOI: 10.12659/AJCR.895474

Published: 2015-11-28

Rare but Lethal Hepatopathy-Sickle Cell Intrahepatic Cholestasis and Management Strategies

Aamir Malik, Chandni Merchant, Mana Rao, Rosemary P. Fiore

Am J Case Rep 2015; 16:840-843

DOI: 10.12659/AJCR.895218