ISSN 1941-5923


Welcome to the American Journal of Case Reports

Clinical case reports are an invaluable first-hand source of evidence in medicine and a tool most often used in practice to exchange information and generate a more expanded search for evidence. In addition to the “evidence of what happened”, single or multiple cases are an important basis for further and more advanced research on diagnosis,  treatment effectiveness, causes and outcomes of disease. However limited their... read more

Published: 2014-10-31

Terlipressin-Induced Ischemic Skin Necrosis: A Rare Association

Banu Demet Ozel Coskun, Ahmet Karaman, Hasan Gorkem, Irfan Buğday, Orhan Kursad Poyrazoğlu, Fatma Senel

(Department of Gastroenterology, Kayseri Training and Research Hospital, Kayseri, Turkey)

Am J Case Rep 2014; 15:476-479

DOI: 10.12659/AJCR.891084

Background: Terlipressin is a synthetic vasopressin analogue that is used in the treatment of bleeding esophageal varices and hepatorenal syndrome in patients with cirrhosis. Serious ischemic adverse events, such as skin necrosis involving the extremities, scrotum, trunk, and abdominal skin, are rarely observed. In the literature to date, 20 cases that developed ischemic skin necrosis due to terlipressin usage have been reported.
Case Report: We report a patient with extensive skin necrosis on the infusion site of the right forearm and hand, which developed after the use terlipressin used to treat bleeding oesophageal varices in a 65-year-old man with cirrhosis.
Conclusions: Although rare, ischemic complications of terlipressin do occur.

Keywords: Liver Cirrhosis, Lypressin, Skin Diseases, Vascular

Published: 2014-10-30

A Case of Adult Granulosa Cell Tumor of the Testis

Stephen B. Tanner, Dan B. Morilla, John D. Schaber

Am J Case Rep 2014; 15:471-475

DOI: 10.12659/AJCR.891389

Published: 2014-10-29

Gallbladder Papillomatosis and Cholecystocolonic Fistula: A Rare Combination

Jenn-Yuan Kuo, Yeun Tarl Fresner Ng Jao

Am J Case Rep 2014; 15:466-470

DOI: 10.12659/AJCR.891190