ISSN 1941-5923

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Welcome to the American Journal of Case Reports

Clinical case reports are an invaluable first-hand source of evidence in medicine and a tool most often used in practice to exchange information and generate a more expanded search for evidence. In addition to the “evidence of what happened”, single or multiple cases are an important basis for further and more advanced research on diagnosis,  treatment effectiveness, causes and outcomes of disease. However limited their... read more


Published: 2015-03-06

Sinus Node Dysfunction Requiring Permanent Pacemaker Implantation in a Young Adult with Klinefelter Syndrome

Ahmet Karagöz, Oğuz Dikbaş, Erhan Teker, Aslı Vural, Zeki Yüksel Günaydın, Osman Bektaş

(Department of Cardiology, Giresun University, Giresun, Turkey)

Am J Case Rep 2015; 16:136-139

DOI: 10.12659/AJCR.893065


Background: Klinefelter syndrome is the most common genetic cause of male infertility and affects approximately 1 in 500 live births. Although accompanying cardiac disorder is not a specific feature of Klinefelter syndrome, rarely associated anomalies such as mitral valve prolapse, atrial septal defect, ventricular septal defect, tetralogy of Fallot, patent ductus arteriosus, and hypertrophic obstructive cardiomyopathy have been reported. A clear association between Klinefelter syndrome and arrhythmic disorders has not yet been demonstrated.
Case Report: We report a case of a sinus node dysfunction that required permanent pacemaker implantation in a young adult with Klinefelter syndrome. The patient was consulted to cardiology clinic due to bradycardia. On physical examination, no cardiac abnormality was detected except for bradycardia. Holter results showed sinus arrhythmia with a minimum heart rate of 33 bpm and maximum of 154 Bpm. There were 3612 ventricular premature beats, 30 ventricular pairs, 804 supraventricular premature beats, 7 supraventricular pairs, and 4 supraventricular runs, the longest of which was 5 beats. The patient had defined dizziness and nausea during Holter monitoring. Electrophysiological study (EPS) was planned because existing findings indicated risk of cardiac syncope. Findings of EPS were interpreted as sinus node dysfunction. A permanent pacemaker implantation was performed and the patient has been free of symptoms since.
Conclusions: This concomitance should be kept in mind when examining patients with Klinefelter syndrome with bradycardia and/or syncope. It is easily mistaken for epilepsy, which is a com... read more

Keywords: Klinefelter Syndrome, Pacemaker, Artificial, sick sinus syndrome




Published: 2015-03-04

Coronary Computed Tomography Angiography of Spontaneous Coronary Artery Dissection: A Case Report and Rev...


Stephanie C. Torres-Ayala, Jose Maldonado, J. Scott Bolton, Sanjeev Bhalla

Am J Case Rep 2015; 16:130-135

DOI: 10.12659/AJCR.892805

Published: 2015-03-01

POEMS Syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy and Skin Changes) Tre...


Carlos Arana, José Antonio Pérez de León, Gerardo Gómez-Moreno, Ramón Pérez-Cano, Tomás Martín Hernández

Am J Case Rep 2015; 16:124-129

DOI: 10.12659/AJCR.892837