ISSN 1941-5923


Colchicine related pancytopenia unresponsive to granulocyte colony stimulating factor

Kaya Sedat, Kararmaz Alper, Karaman Haktan, Turhanoglu Selim

CaseRepClinPractRev 2007; 8:13-15

ID: 467998

Published: 2007-01-03

Background: Colchicine overdose is uncommon but extremely serious and it is associated with considerable mortality. Previous reports have shown that granulocyte colony-stimulating factor therapy was an effective method of treating the colchicine related pancytopenia.
Case Reports: We describe a case of suicidal ingestion of 15 mg of colchicine in a previously healthy 23-yearsold woman. During nasogastric tube insertion, nasal bleeding developed in the emergency room and stopped after anterior nasal tamponage. Following days, patient’s platelet counts decreased
to 14.9 K/UL due to bone marrow suppression. In spite of all therapeutic approach including granulocyte colony-stimulating factor, our patient died on 5th day due to severe bleeding.
Conclusions: Bone marrow suppression may be resistant to granulocyte colony-stimulating factor in colchicine poisoning. We recommend that all invasive procedures were performed more carefully in patient
doubted colchicine ingestion.

Keywords: Colchicine, Intoxication, Granulocyte Colony-Stimulating Factor