01 December 2002
Glioblastoma multiforme following Bragg proton beam
radiosurgery for cerebral arteriovenous malformation:
complication or association?
Rainer Ritz, Dirk Freudenstein, Udo Bühring, Ulrich Krüth, Antje Bornemann, Frank Duffner
Case Rep Clin Pract Rev 2002; 3(4):219-223 :: ID: 474435
Abstract
Background: Stereotactic radiosurgery has become a widespread treatment alternative especially in benign central nervous system lesions. So far, only a few cases of photon beam radiosurgery-induced oncogenesis have been
reported.
Case report: The authors report a patient who underwent Bragg proton beam radiosurgery through two bi-occipital portals for a surgically inaccessible left-sided occipital high-flow arteriovenous malformation (AVM). 19 years
after irradiation, the patient developed a mild left-sided hemiparesis together with a progressive change of his mental status. Magnetic resonance imaging (MRI) demonstrated a predominantely cystic fronto-polar lesion on
the right side. Neuropathological investigation after microsurgical resection revealed a glioblastoma multiforme (WHO IV°). Based on a thorough review of the literature, this constellation had not been described previously.
Conclusions: Despite the common use of stereotactic radiosurgery in any application, the risk of delayed cerebral neoplasia reported to occur after fractionated irradiation still remains to be clarified. In the presented case, the
causal relationship between proton beam radiosurgery and formation of a malignant brain tumor is discussed.
Keywords: stereotactic radiosurgery, proton beam, radiation-induced tumor, glioblastoma multiforme, cerebral arteriovenous malformation
42
In Press
19 Mar 2024 : Case report
Jejunal Diverticulosis Causing Small Intestinal Volvulus and Closed Loop ObstructionAm J Case Rep In Press; DOI: 10.12659/AJCR.943376
19 Mar 2024 : Case report
Excimer Laser Therapy for Pigmented Purpuric Dermatosis: A Case StudyAm J Case Rep In Press; DOI: 10.12659/AJCR.942853
19 Mar 2024 : Case report
Case Report: Primary Cutaneous Histoplasmosis in an Immunocompetent Patient After Cosmetic Injection of Pla...Am J Case Rep In Press; DOI: 10.12659/AJCR.942660
19 Mar 2024 : Case report
Bilateral Simultaneous Basal Ganglia Hemorrhage: A Case ReportAm J Case Rep In Press; DOI: 10.12659/AJCR.943174
Most Viewed Current Articles
07 Mar 2024 : Case report
Neurocysticercosis Presenting as Migraine in the United StatesDOI :10.12659/AJCR.943133
Am J Case Rep 2024; 25:e943133
10 Jan 2022 : Case report
A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...DOI :10.12659/AJCR.935263
Am J Case Rep 2022; 23:e935263
19 Jul 2022 : Case report
Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19DOI :10.12659/AJCR.936128
Am J Case Rep 2022; 23:e936128
23 Feb 2022 : Case report
Penile Necrosis Associated with Local Intravenous Injection of CocaineDOI :10.12659/AJCR.935250
Am J Case Rep 2022; 23:e935250