01 June 2002
Angiogenic stimuli in cystic tumoral calcinosis (Teutschländer Disease)
Zygmunt Mackiewicz, Danute Povilenaite, Mindaugas Minderis, Vida Graziene, Arvydas Rimkevicius, Yrjö T. KonttinenCase Rep Clin Pract Rev 2002; 3(2):76-81 :: ID: 474532
Abstract
Background: A case of cystic tumoral calcinosis (Teutschländer disease) developed by a patient who had had a juvenile idiopathic dermatomyositis in childhood is presented in general terms. Microscopic examination of
the surgical specimens of tumor masses is analyzed in more detail. Concomitant pathologies were a transient disorder in lipid metabolism and psoriasis.
Case Report: The patient with cystic tumoral calcinosis (Teutschländer disease) developed in childhood after juvenile idiopathic dermatomyositis is presented. Physical, radiological and histological findings are described.
Confluent calcified nodules filled with chalky organic fluid masses and concretions grew slowly reaching imposing dimensions. They occupied subcutaneous spaces of the extremities causing pressure upon surrounding tissues and secondary symptoms of compression of the muscles and nerves. The histology of cystic nodules was similar in all affected limbs. No recurrence occurred after surgical extirpation of tumor masses. Concomitant pathologies were a transient disorder in lipid metabolism and slowly progressing psoriasis.
Conclusion: Teutschländer disease is a condition of unknown etiology and tangled pathogenesis. A strong expression of the angiogenic factor was found in outer sheets of cystic masses. Total ablation of calcified tumor
masses provided satisfactory therapeutic results and no recurrence.
Keywords: Teutchländer disease, cystic calcinosis, dermatomyositis, angiogenesis
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