01 January 2003
Malignant pericardial effusion and osteosclerotic metastasis in gastric adenocarcinoma
Emmanouil Peros, Mario N. Piccinni, Enzo Emanuele, Apostolos Kalakonas, Angeliki Smponia, Piercarlo Minoretti, Diego GeroldiCase Rep Clin Pract Rev 2003; 4(4):322-325 :: ID: 476424
Abstract
Background: Malignant pericardial effusion is a rare entity in stomach cancer, since it has been reported in only six patients. Osteosclerotic bone metastasis are similarly unusual, with five patients described in the literature.
Case report: A 39-year-old man was referred to our department for dry cough and dyspnea. The chest radiography evidenced a remarkable enlargment of the cardiac profile and echocardiography revealed massive pericardial effusion. A diagnosis of cardiac tamponade was made and pericardiocentesis was performed. Cytological analysis of the pericardial fluid disclosed cells consistent with adenocarcinoma, suggesting a malignant effusion. The patient showed high serum levels of alkaline phosphatase and total body X-ray scan revealed diffuse osteosclerosis of the cervico-thoracic-lumbar spine, shoulders, proximal humerus and femurs. Bone marrow
biopsy was performed and evidenced metastatic adenocarcinoma with increased osteoblastic activity. A search for the primary site was done and esophagogastroduodenoscopy disclosed gastric cancer. The histological examination revealed poorly differentiated adenocarcinoma. Therefore, the final diagnosis was advanced gastric cancer with osteosclerotic bone
metastasis and pericarditis carcinomatosa with pericardial effusion.
Conclusions: Although the contemporary presence of both cardiac tamponade and diffuse osteosclerotic skeletal metastasis has not been previously reported in patients with gastric adenocarcinoma, stomach malignancies should be considered in differential diagnosis of malignant pericardial
effusion and/or osteosclerotic skeletal metastasis.
Keywords: Gastric adenocarcinoma, malignant pericardial effusion, osteosclerotic metastasis
27
In Press
14 Mar 2024 : Case report
Laparoscopic Sleeve Gastrectomy with Staple-Line Oversewing in a Patient with Factor XI Deficiency: A Case ...Am J Case Rep In Press; DOI: 10.12659/AJCR.942824
14 Mar 2024 : Case report
Pathogenic Potential of a PCK1 Gene Variant in Cytosolic PEPCK Deficiency: A Compelling Case StudyAm J Case Rep In Press; DOI: 10.12659/AJCR.943118
14 Mar 2024 : Case report
Management of Nontraumatic Spontaneous Renal Hemorrhage (Wünderlich Syndrome) through Robotic-Assisted Lapa...Am J Case Rep In Press; DOI: 10.12659/AJCR.942826
14 Mar 2024 : Case report
Simultaneous Occurrence of Collagen Type III Glomerulopathy and Immunoglobulin A Nephropathy: A Rare Case R...Am J Case Rep In Press; DOI: 10.12659/AJCR.942770
Most Viewed Current Articles
07 Mar 2024 : Case report
Neurocysticercosis Presenting as Migraine in the United StatesDOI :10.12659/AJCR.943133
Am J Case Rep 2024; 25:e943133
10 Jan 2022 : Case report
A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...DOI :10.12659/AJCR.935263
Am J Case Rep 2022; 23:e935263
19 Jul 2022 : Case report
Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19DOI :10.12659/AJCR.936128
Am J Case Rep 2022; 23:e936128
23 Feb 2022 : Case report
Penile Necrosis Associated with Local Intravenous Injection of CocaineDOI :10.12659/AJCR.935250
Am J Case Rep 2022; 23:e935250