ISSN 1941-5923


Nodular subcutaneous metastases of bronchogenic carcinoma

Demetrio Tamiolakis, Ioannis Venizelos, Maria Lambropoulou, Despoina Kakagia, George Alexiadis, George Petrakis, Nikolas Papadopoulos

CaseRepClinPractRev 2007; 8:48-51

ID: 476510

Published: 2007-02-28

Background: Cancer metastasis represents the most devastating aspect of malignancy since mortality of tumour hosts is mainly related to the metastatic behaviour of the primary neoplasm. In general, cancers that often metastasize to other organs also do so to the skin. Thus, lung cancer with its
recognized propensity for spread to brain, bone, liver, and adrenal glands, is responsible for the bulk of skin metastases in men and is second only to breast cancer in women.
Case Report: A 82-year-old man with a long history of smoking presented with several painful lumps all over his anterior trunk during a 4 month period, without any systemic complaint. Clinical and radiological work-up revealed right upper lobe consolodation which proved to be secondary
to bronchogenic carcinoma. Cytological findings from a fine needle aspiration biopsy from a subcutaneous lump were consistent with metastatic adenocarcinoma. Histopathological examination revealed features of inflammatory cutaneous metastasis. Immunohistochemical
studies showed a positive staining with anti-cytokeratin, anti-EMA, and anti-CEA antibodies. Interestingly, this was the presenting feature of the underlying malignancy in this patient.
Conclusions: Inflammatory cutaneous metastatic bronchogenic carcinoma is characterized by suggestive clinical and pathological features and is usually associated with advanced stages of the disease.

Keywords: Bronchogenic carcinoma, inflammatory skin metastasis, carcinoma erysipelatoides