Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

08 May 2007

Uneven element distribution in alcoholic liver disease.
A case report

Gavino Faa, Guido Crisponi, Clara Gerosa, Stefania Lecca, Daniela Fanni, Rosalba Pinna, Valeria Marina Nurchi

Case Rep Clin Pract Rev 2007; 8:132-138 :: ID: 481662

Abstract

Background: Chronic ethanol consumption is often associated with modifications in the liver content of several trace elements. Being associated with ongoing fibrogenesis, increases in iron and copper and the decrease in zinc liver stores may play a significant role in the progression of alcoholic liver disease (ALD). It seemed of interest to determine the hepatic Fe, Cu, Zn,
P, S, and Mg distribution in an autoptic case of ALD.
Case Report: A liver slice was divided into 63 samples, and each one in two symmetrical parts: one was utilized to quantify trace elements by Induced Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES).
Our data confirm that ALD is associated with marked changes in trace element status in the liver. In particular, the increase in iron and copper and the decrease in zinc are confirmed. Moreover, we give evidence of an irregular, uneven distribution of all elements studied throughout the liver, with marked differences in content even among adjacent samples.
Conclusions: Given the observed sampling variability of all studied elements, we suggest caution when considering the dosage obtained from a small part of a liver needle biopsy for clinical purposes as representative of the mean metal liver content.

Keywords: Alcoholic liver disease, Trace Elements, Copper, Zinc, ICP-AES

Add Comment 0 Comments

20

In Press

12 Feb 2024 : Case report  Germany

Diagnostic Challenges and Imaging Considerations for Intraparotid Facial Nerve Schwannoma: A Case Report an...

Am J Case Rep In Press; DOI: 10.12659/AJCR.942870  

0:00

12 Feb 2024 : Case report  USA

Erdheim-Chester Disease Occult on Radiographs and CT but Visible on MRI and PET

Am J Case Rep In Press; DOI: 10.12659/AJCR.941169  

0:00

12 Feb 2024 : Case report  USA

Surgical Treatment of Spontaneous Superficial Temporal Artery Arteriovenous Malformation: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.942839  

13 Feb 2024 : Case report  Bahrain

Warfarin Woes: A Rare Case of Hemoperitoneum with Intramural Small Bowel Hematoma

Am J Case Rep In Press; DOI: 10.12659/AJCR.943519  

Most Viewed Current Articles

10 Jan 2022 : Case report  Germany

A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...

DOI :10.12659/AJCR.935263

Am J Case Rep 2022; 23:e935263

19 Jul 2022 : Case report  Saudi Arabia

Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19

DOI :10.12659/AJCR.936128

Am J Case Rep 2022; 23:e936128

05 Mar 2022 : Case report  Brazil

Acute Limb Ischemia After Self-Injection of Crushed Morphine Tablets into the Radial Artery: Role of Infrar...

DOI :10.12659/AJCR.935336

Am J Case Rep 2022; 23:e935336

02 Apr 2022 : Case report  Saudi Arabia

Infective Endocarditis Caused by Pseudomonas luteola in a Pediatric Patient. A Case Report and Review of Li...

DOI :10.12659/AJCR.935743

Am J Case Rep 2022; 23:e935743

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923