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Epithelial Dysplasia in Ameloblastic Fibrosarcoma Arising from Recurrent Ameloblastic Fibroma in a 26-Year-Old Iranian Man

Zhaleh Mohsenifar, Samira Behrad, Fatemeh Mashhadi Abbas

(Department of Pathology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran)

Am J Case Rep 2015; 16:548-553

DOI: 10.12659/AJCR.892284

Published: 2015-08-18


BACKGROUND: Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumor with a mesenchymal component, showing sarcomatous features and epithelial nests resembling ameloblastic fibroma (AF).
CASE REPORT: We report a case of AFS showing epithelial dysplasia arising in a recurrent AF in the left mandible after 3 years in a 26-year-old man, which is regarded as an uncommon histopathologic finding in AFS. We also emphasize the comprehensive clinical, radiographic, and histopathologic evaluation, and immunohistochemical staining of this patient.
CONCLUSIONS: We conclude that it is important to consider malignancy alternations in the epithelial component of AFS, along with that of the mesenchymal component, to provide a proper diagnosis and treatment of recurrent AF.

Keywords: Adult, Fibroma - surgery, Fibrosarcoma - surgery, Humans, Iran, Male, Mandibular Neoplasms - surgery, Neoplasm Recurrence, Local - surgery, Odontogenic Tumors - surgery



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