01 January 2005
Autoimmune Cerebellar Ataxia in a 14 year-old boy with Type 1 Diabetes Mellitus
Parmjit K. Gill, Ayse Pinar CemerogluCase Rep Clin Pract Rev 2005; 6:164-167 :: ID: 428847
Abstract
Background: Glutamic acid decarboxylase (GAD) is an enzyme present in central nervous system and in many other tissues including pancreas. It catalyses conversion of glutamate to gama-aminobutyric acid. Anti-GAD autoantibodies are present in 80% of patients at the time of diagnosis of type 1 Diabetes Mellitus. The link between presence of anti-GAD antibodies in Stiff-man syndrome has been known for years. However, recently, coexistence of cerebellar ataxia in patients with type 1 Diabetes Mellitus indicated a link between anti-GAD antibodies and cerebellar ataxia in adults. However, this is the first pediatric case with cerebellar ataxia and type 1 Diabetes Mellitus in children.Case Report: A 14 year-old boy who initially presented with cerebellar ataxia at age 11 years, was diagnosed with type 1 Diabetes Mellitus. The diagnostic work-up for cerebellar ataxia including metabolic studies, genetic study for Friedreich ataxia, and MRI of the brain were negative. He had a very high serum titer of anti-GAD antibodies at the time of and 2 years after the diagnosis of type 1 Diabetes Mellitus.Conclusions: Presence of anti-GAD antibodies in children may cause autoimmune cerebellar ataxia years before the onset of overt Type 1 Diabetes Mellitus. Therefore, in cases with cerebellar ataxia of unknown etiology in children, anti-GAD antibodies in serum or cerebrospinal fluid should be measured, not only to determine the etiology of ataxia but also to determine the future risk of other autoimmune endocrinopathies.
Keywords: Anti-Glutamic Acid Decarboxylase antibody, Autoimmunity, Cerebellar Ataxia, type 1 diabetes mellitus
32
In Press
16 Mar 2024 : Case report
A Rare Autochthonous Case of Hepatic Hydatid Cyst in the Non-Endemic Region of TaiwanAm J Case Rep In Press; DOI: 10.12659/AJCR.943687
17 Mar 2024 : Case report
Contrast-Enhanced Ultrasonography in Diagnosing Intravascular Large B-Cell Lymphoma Infiltrating Liver Sinu...Am J Case Rep In Press; DOI: 10.12659/AJCR.943070
17 Mar 2024 : Case report
Rare Presentation of Rapidly Involuting Congenital Hemangioma of the Skull: A Case ReportAm J Case Rep In Press; DOI: 10.12659/AJCR.943370
18 Mar 2024 : Case report
Perineal Benign Symmetric Lipomatosis in a Female Patient: A Case ReportAm J Case Rep In Press; DOI: 10.12659/AJCR.943803
Most Viewed Current Articles
07 Mar 2024 : Case report
Neurocysticercosis Presenting as Migraine in the United StatesDOI :10.12659/AJCR.943133
Am J Case Rep 2024; 25:e943133
10 Jan 2022 : Case report
A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...DOI :10.12659/AJCR.935263
Am J Case Rep 2022; 23:e935263
19 Jul 2022 : Case report
Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19DOI :10.12659/AJCR.936128
Am J Case Rep 2022; 23:e936128
23 Feb 2022 : Case report
Penile Necrosis Associated with Local Intravenous Injection of CocaineDOI :10.12659/AJCR.935250
Am J Case Rep 2022; 23:e935250