01 October 2003
Disseminated superficial actinic porokeratosis in a patient with B-cell chronic lymphocytic leukaemia treated with cladribine and cyclophosphamide
Ewa Robak, Jacek Bartkowiak, Tadeusz RobakCase Rep Clin Pract Rev 2003; 4(3):163-168 :: ID: 450613
Abstract
Background: Disseminated superficial porokeratosis (DSAP) is a skin disorder of epidermal keratinisation characterized by diffuse small lesions, distributed over the legs, the arms and trunk. Acquired forms have been reported in immunocompromised patients including patients with AIDS. The occurrence of DSAP after treatment with new immunosupresive agent – cladribine (2-chlorodeoxyadenosine, 2-CdA) has not been reported so far.
Case report: Here, we report a case of disseminated superficial actinic porokeratosis (DSAP) in a white, 67 years old man, six years after diagnosis of B-cell chronic lymphocytic leukemia (B-CLL). In August 2000 a few erythematous macules and papules on the extensor surface of his legs were noted. Four months later the patient was treated with three courses of cladribine (2-CdA) and cyclophosphamide (CC protocol), because of CLL progression. During the treatment he experienced significant gradual worsening of the cutaneous eruptions. Histologic examination of biopsy specimens taken from the skin changes revealed typical features of porokeratosis
including the characteristic cornoid lamellae. Morphological and molecular investigations excluded
leukemic infiltration of the skin.
Conclusions: The development of DSAP in our patient may suggest that this complication observed earlier in
patients with AIDS is also possible after the treatment with 2-CdA, the agent which induces long – lasting, severe immunosuppresion. We suggest that porkeratosis should be included in the group of skin diseases occurring in patients with B-CLL and complications of 2-CdA treatment.
Keywords: Porokeratosis, DSAP, Chronic lymphocytic leukemia, cladribine, Cyclophosphamide, immunosuppresion, skin disorders
36
In Press
12 Feb 2024 : Case report
Diagnostic Challenges and Imaging Considerations for Intraparotid Facial Nerve Schwannoma: A Case Report an...Am J Case Rep In Press; DOI: 10.12659/AJCR.942870
12 Feb 2024 : Case report
Erdheim-Chester Disease Occult on Radiographs and CT but Visible on MRI and PETAm J Case Rep In Press; DOI: 10.12659/AJCR.941169
12 Feb 2024 : Case report
Surgical Treatment of Spontaneous Superficial Temporal Artery Arteriovenous Malformation: A Case ReportAm J Case Rep In Press; DOI: 10.12659/AJCR.942839
13 Feb 2024 : Case report
Warfarin Woes: A Rare Case of Hemoperitoneum with Intramural Small Bowel HematomaAm J Case Rep In Press; DOI: 10.12659/AJCR.943519
Most Viewed Current Articles
10 Jan 2022 : Case report
A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...DOI :10.12659/AJCR.935263
Am J Case Rep 2022; 23:e935263
19 Jul 2022 : Case report
Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19DOI :10.12659/AJCR.936128
Am J Case Rep 2022; 23:e936128
05 Mar 2022 : Case report
Acute Limb Ischemia After Self-Injection of Crushed Morphine Tablets into the Radial Artery: Role of Infrar...DOI :10.12659/AJCR.935336
Am J Case Rep 2022; 23:e935336
02 Apr 2022 : Case report
Infective Endocarditis Caused by Pseudomonas luteola in a Pediatric Patient. A Case Report and Review of Li...DOI :10.12659/AJCR.935743
Am J Case Rep 2022; 23:e935743