03 January 2007
Colchicine related pancytopenia unresponsive to granulocyte colony stimulating factor
Kaya Sedat, Kararmaz Alper, Karaman Haktan, Turhanoglu SelimCase Rep Clin Pract Rev 2007; 8:13-15 :: ID: 467998
Abstract
Background: Colchicine overdose is uncommon but extremely serious and it is associated with considerable mortality. Previous reports have shown that granulocyte colony-stimulating factor therapy was an effective method of treating the colchicine related pancytopenia.
Case Reports: We describe a case of suicidal ingestion of 15 mg of colchicine in a previously healthy 23-yearsold woman. During nasogastric tube insertion, nasal bleeding developed in the emergency room and stopped after anterior nasal tamponage. Following days, patient’s platelet counts decreased
to 14.9 K/UL due to bone marrow suppression. In spite of all therapeutic approach including granulocyte colony-stimulating factor, our patient died on 5th day due to severe bleeding.
Conclusions: Bone marrow suppression may be resistant to granulocyte colony-stimulating factor in colchicine poisoning. We recommend that all invasive procedures were performed more carefully in patient
doubted colchicine ingestion.
Keywords: Colchicine, Intoxication, Granulocyte Colony-Stimulating Factor
22
In Press
12 Feb 2024 : Case report
Erdheim-Chester Disease Occult on Radiographs and CT but Visible on MRI and PETAm J Case Rep In Press; DOI: 10.12659/AJCR.941169
12 Feb 2024 : Case report
Surgical Treatment of Spontaneous Superficial Temporal Artery Arteriovenous Malformation: A Case ReportAm J Case Rep In Press; DOI: 10.12659/AJCR.942839
13 Feb 2024 : Case report
Warfarin Woes: A Rare Case of Hemoperitoneum with Intramural Small Bowel HematomaAm J Case Rep In Press; DOI: 10.12659/AJCR.943519
13 Feb 2024 : Case report
Hemorrhagic Presentation in Primary Central Nervous System Lymphoma: A Case StudyAm J Case Rep In Press; DOI: 10.12659/AJCR.942951
Most Viewed Current Articles
07 Mar 2024 : Case report
Neurocysticercosis Presenting as Migraine in the United StatesDOI :10.12659/AJCR.943133
Am J Case Rep 2024; 25:e943133
10 Jan 2022 : Case report
A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...DOI :10.12659/AJCR.935263
Am J Case Rep 2022; 23:e935263
19 Jul 2022 : Case report
Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19DOI :10.12659/AJCR.936128
Am J Case Rep 2022; 23:e936128
23 Feb 2022 : Case report
Penile Necrosis Associated with Local Intravenous Injection of CocaineDOI :10.12659/AJCR.935250
Am J Case Rep 2022; 23:e935250