01 February 2001
Angiotensin-converting enzyme inhibitors – a new class of coronary drugs
Andrzej RynkiewiczCase Rep Clin Pract Rev 2001; 2(2):153-162 :: ID: 475220
Abstract
The renin-angiotensin-aldosterone system is the main regulator of arterial blood pressure and water-electrolyte homeostasis. We have currently at our disposal more and more evidence indicating the possibility of local renin-angiotensin-aldosterone systems existing in blood vessels, brain, heart or kidneys and regulated independently of the systemic one. One of the essential elements of this system is the enzyme converting angiotensin I (ACE-angiotensin converting enzyme), which is responsible for the synthesis of an active octapeptide - angiotensin II. (Ang II) as well as for degradation of bradykinin to inactive peptides. There seems to be convincing, theoretical, experimental and clinical evidence pointing to potential usefulness of this type of drugs in treatment of coronary heart disease. Inhibition of Ang II formation, both on systemic and tissue level, improves the function of endothelium, stabilizes the atheromatous plaque and reverses pathologic changes in the heart and blood vessels. Varying affinity of different drugs belonging to the ACE inhibitor group to tissue angiotensin-converting enzyme may have a significant effect on the therapeutic efficacy in treatment of patients with coronary heart disease. ACE inhibitors may not only improve the clinical condition of patients with ischemic heart disease, but may also have positive effect on the prognosis.
Keywords: ACE inhibitions, coronary heart disease, prevention
24
In Press
12 Mar 2024 : Case report
Successful Treatment of Lithium-Induced Nephrogenic Diabetes Insipidus with Celecoxib: A Promising Therapeu...Am J Case Rep In Press; DOI: 10.12659/AJCR.943244
13 Mar 2024 : Case report
Recurrent Marginal Zone Lymphoma with Bone Marrow Involvement Detected by ¹⁸F-FDG PET/CT and Biopsy: A Diag...Am J Case Rep In Press; DOI: 10.12659/AJCR.943275
13 Mar 2024 : Case report
Unveiling the Temporal Aspect of MRI Tattoo Reactions: A Prospective Evaluation of a Newly-Acquired Tattoo ...Am J Case Rep In Press; DOI: 10.12659/AJCR.943411
13 Mar 2024 : Case report
Cardiac and Intramuscular Metastases Following Nephroureterectomy for Metachronous Urothelial CarcinomaAm J Case Rep In Press; DOI: 10.12659/AJCR.942864
Most Viewed Current Articles
07 Mar 2024 : Case report
Neurocysticercosis Presenting as Migraine in the United StatesDOI :10.12659/AJCR.943133
Am J Case Rep 2024; 25:e943133
10 Jan 2022 : Case report
A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...DOI :10.12659/AJCR.935263
Am J Case Rep 2022; 23:e935263
19 Jul 2022 : Case report
Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19DOI :10.12659/AJCR.936128
Am J Case Rep 2022; 23:e936128
23 Feb 2022 : Case report
Penile Necrosis Associated with Local Intravenous Injection of CocaineDOI :10.12659/AJCR.935250
Am J Case Rep 2022; 23:e935250