Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

08 November 2011

Cutaneous Langerhans cell histiocytosis: Report of two cases

Sharma Utsav, Songmei Geng

DOI: 10.12659/AJCR.882097

Am J Case Rep 2011; 12:154-158

Abstract

Abstract
Background: Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of Langerhans cells, with a broad spectrum of clinical manifestation and prognosis. Here, we present 2 cases of cutaneous LCH in young children with good prognosis.
Case Report: A 6-month-old girl showed generalized multiple reddish-brown papules with crust over the trunk. The second patient was a boy aged 2.5 years who also presented with generalized papules with crust and ulcers over the trunk and was treated for eczema and psoriasis with no improvement. In both cases, routine laboratory and radiological examinations were normal, and skin biopsies revealed atrophic epidermis and a dense infiltration of large histiocytic cells with eosinophilic cytoplasm and reniform nuclei. The histiocytes were positive for S100 and CD1a, thus confirming the diagnosis of LCH. Both patients were prescribed chemotherapy including prednisone, vincristine, and azathioprine for 6 months.
Conclusions: Through this case report, we wish to emphasize the importance of both histopathological and immunohistochemical confirmation for the diagnosis of cutaneous manifestations of LCH, as well as recommending a long-term follow-up to monitor recovery and evidence of relapse.

Keywords: langerhans cell histiocytosis, cutaneous, children

Add Comment 0 Comments

In Press

12 Feb 2024 : Case report  Germany

Diagnostic Challenges and Imaging Considerations for Intraparotid Facial Nerve Schwannoma: A Case Report an...

Am J Case Rep In Press; DOI: 10.12659/AJCR.942870  

0:00

12 Feb 2024 : Case report  USA

Erdheim-Chester Disease Occult on Radiographs and CT but Visible on MRI and PET

Am J Case Rep In Press; DOI: 10.12659/AJCR.941169  

0:00

12 Feb 2024 : Case report  USA

Surgical Treatment of Spontaneous Superficial Temporal Artery Arteriovenous Malformation: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.942839  

13 Feb 2024 : Case report  Bahrain

Warfarin Woes: A Rare Case of Hemoperitoneum with Intramural Small Bowel Hematoma

Am J Case Rep In Press; DOI: 10.12659/AJCR.943519  

Most Viewed Current Articles

10 Jan 2022 : Case report  Germany

A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...

DOI :10.12659/AJCR.935263

Am J Case Rep 2022; 23:e935263

19 Jul 2022 : Case report  Saudi Arabia

Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19

DOI :10.12659/AJCR.936128

Am J Case Rep 2022; 23:e936128

05 Mar 2022 : Case report  Brazil

Acute Limb Ischemia After Self-Injection of Crushed Morphine Tablets into the Radial Artery: Role of Infrar...

DOI :10.12659/AJCR.935336

Am J Case Rep 2022; 23:e935336

02 Apr 2022 : Case report  Saudi Arabia

Infective Endocarditis Caused by Pseudomonas luteola in a Pediatric Patient. A Case Report and Review of Li...

DOI :10.12659/AJCR.935743

Am J Case Rep 2022; 23:e935743

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923