ISSN 1941-5923

Logo



Get your full text copy in PDF

Adalimumab (Humira) induced acute lung injury

Ritesh Kohli, Karim Namek

(Bridgeport, USA)

Am J Case Rep 2013; 14:173-175

DOI: 10.12659/AJCR.889200


Background: Adalimumab is a recombinant human monoclonal antibody that blocks the effects of tumor necrosis factor-alpha. Adalimumab related acute lung injury is a rare form of acute respiratory distress syndrome of possible immune etiology that develops immediately after an infusion.
Case Report: We describe a 78 year old, male with no previous cardiac comorbidities, who developed acute lung injury (ALI) within one hour of administration of adalimumab. He was successfully treated with mechanical ventilatory support and adjuvant therapy.
Conclusions: TNFalpha antagonists are a part of a new and revolutionary treatment for severe and difficult-to-treat autoimmune and inflammatory diseases.This report emphasizes that this fatal complication may occur with use of this drug.Clinicians need to be aware of this condition as prompt recognition and supportive management can prevent unwanted morbidity and mortality.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree