ISSN 1941-5923

Logo



Get your full text copy in PDF

Quantitative MR Markers and Psychiatric Symptoms in a Patient with Fahr Disease

Viviana Lo Buono, Francesco Corallo, Antonio Costa, Placido Bramanti, Silvia Marino

(Institute of Hospitalization and Care Scientific (IRCCS), Centro Neurolesi “Bonino Pulejo”, Messina, Italy)

Am J Case Rep 2015; 16:382-385

DOI: 10.12659/AJCR.893163


BACKGROUND: Fahr’s disease (FD), or primitive idiopathic calcification of the basal ganglia, is a rare neurodegenerative syndrome characterized by the presence of idiopathic bilateral and symmetrical cerebral calcifications.
CASE REPORT: We describe the case of 43-year-old woman presenting with psychiatric symptoms, disorganized behavior, and migraine. Magnetic resonance imaging (MRI) examination showed basal ganglia calcifications. In addition, we analyzed the cortical brain volume and noted cortical atrophy. Extensive etiological clinico-biological assessment allowed us to exclude known causes of brain calcifications and to diagnose Fahr disease (FD). Neurological symptoms associated with psychiatric manifestations are not uncommon in FD.
CONCLUSIONS: Purely psychiatric presentations are possible, as demonstrated by the present case, although there have been very few cases reported. To date, no studies related to the brain atrophy in FD have been reported.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree