Figure 4. (A) Showed histological sections reveal densely cellular neoplasia consisting of polygonal ovoid round cells and fusiform with signs of anaplasia evidenced by macronucleosis, hyperchromatism, pleomorphism, and intense mitotic activity (>25×10) with alteration of the polarity and the nucleus-cytoplasm relationship. (B, C) Showed areas of necrosis surrounded by viable tumor cell palisades, as well as proliferation of glomeruloid vessels of swollen endothelium, typical of high-grade gliomas. (D) Showed immuno-staining for glial fibrillary acidic protein (GFAP) is intensely positive in tumor cells and verifies their glial lineage.