A Patient with 22q11.2 Deletion Syndrome Presenting with Systemic Skin Rash and Dermatopathic Lymphadenitis of Unusual Histology

Yoshiro Otsuki; Hiroshi Kobayashi; Yoshifumi Arai; Nao Inoue; Tadashi Matsubayashi; Masaaki Koide; Mitsunori Yamakawa

doi:10.12659/AJCR.924961

26 August 2020 : Case report Japan

A Patient with 22q11.2 Deletion Syndrome Presenting with Systemic Skin Rash and Dermatopathic Lymphadenitis of Unusual Histology

Rare coexistence of disease or pathology

Yoshiro Otsuki^1ABCDEF*, Hiroshi Kobayashi^12ACDEF, Yoshifumi Arai^1CDEF, Nao Inoue^3BCDE, Tadashi Matsubayashi^4BCDE, Masaaki Koide^5BCDE, Mitsunori Yamakawa^6ACDEF

DOI: 10.12659/AJCR.924961

Am J Case Rep 2020; 21:e924961

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Figure 1. Pathological features of the skin. (A) DOL33, a skin biopsy, demonstrated vacuolar interface dermatitis with superficial perivascular infiltration (hematoxylin and eosin staining (H&E), ×75). (B) Grossly, an autopsy revealed that severe erythroderma with cutaneous erosions and hemorrhages was widely distributed. (C) Microscopically, the epidermis showed an erosive and necrotic change with bacterial infection, and the dermis exhibited severe inflammatory cell infiltration in the autopsy (H&E, ×75).

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A Patient with 22q11.2 Deletion Syndrome Presenting with Systemic Skin Rash and Dermatopathic Lymphadenitis of Unusual Histology

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