17 September 2020>: Articles
Delayed Fulminant Hepatic Failure from Dydrogesterone-Related Fertilization Therapy Requiring Liver Transplantation During Pregnancy
Unusual clinical course, Unusual or unexpected effect of treatment, Unexpected drug reactionJacques A.J. Malherbe A , George Garas A , Tze S. Khor A , Gerry C. MacQuillan A*
Am J Case Rep 2020; 21:e925690
Figure 1. Longitudinal biochemical data illustrating the patient’s progressive hepatic failure since her hospital admission (day 0). Transplantation occurred at day 24 with subsequent post-transplant biochemical data illustrated thereafter by gray shading. (A) Alanine aminotransferase (ALT, blue) and aspartate aminotransferase (AST, red) parameters showing initial significant transaminitis with progressive normalization post-liver transplantation. Hepatic failure was further illustrated by progressive (B) hyperbilirubinemia (red), thrombocytopenia (blue), (C) hypoalbuminemia, and (D) coagulopathy (international normalized ratio [INR]). Post-transplantation, all parameters normalized.