17 September 2020
: Case report
Delayed Fulminant Hepatic Failure from Dydrogesterone-Related In Vitro Fertilization Therapy Requiring Liver Transplantation During Pregnancy
Unusual clinical course, Unusual or unexpected effect of treatment, Unexpected drug reaction
Jacques A.J. Malherbe12ABCDEF, George Garas123ABCDEF, Tze S. Khor4ABCDE, Gerry C. MacQuillan123ABCDEF*DOI: 10.12659/AJCR.925690
Am J Case Rep 2020; 21:e925690
Figure 1. Longitudinal biochemical data illustrating the patient’s progressive hepatic failure since her hospital admission (day 0). Transplantation occurred at day 24 with subsequent post-transplant biochemical data illustrated thereafter by gray shading. (A) Alanine aminotransferase (ALT, blue) and aspartate aminotransferase (AST, red) parameters showing initial significant transaminitis with progressive normalization post-liver transplantation. Hepatic failure was further illustrated by progressive (B) hyperbilirubinemia (red), thrombocytopenia (blue), (C) hypoalbuminemia, and (D) coagulopathy (international normalized ratio [INR]). Post-transplantation, all parameters normalized.