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17 September 2020: Articles

Delayed Fulminant Hepatic Failure from Dydrogesterone-Related Fertilization Therapy Requiring Liver Transplantation During Pregnancy

Unusual clinical course, Unusual or unexpected effect of treatment, Unexpected drug reaction

Jacques A.J. Malherbe A , George Garas A , Tze S. Khor A , Gerry C. MacQuillan A*

DOI: 10.12659/AJCR.925690

Am J Case Rep 2020; 21:e925690

Figure 1. Longitudinal biochemical data illustrating the patient’s progressive hepatic failure since her hospital admission (day 0). Transplantation occurred at day 24 with subsequent post-transplant biochemical data illustrated thereafter by gray shading. (A) Alanine aminotransferase (ALT, blue) and aspartate aminotransferase (AST, red) parameters showing initial significant transaminitis with progressive normalization post-liver transplantation. Hepatic failure was further illustrated by progressive (B) hyperbilirubinemia (red), thrombocytopenia (blue), (C) hypoalbuminemia, and (D) coagulopathy (international normalized ratio [INR]). Post-transplantation, all parameters normalized.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923