08 April 2021: Articles
A 58-Year-Old Woman with Acute Gastric Perforation Due to Metastatic Ductal Carcinoma 18 Years Following Bilateral Mastectomy for Invasive Ductal Carcinoma of the Breast
Unusual clinical course, Challenging differential diagnosis, Diagnostic / therapeutic accidents, Unusual setting of medical care, Educational Purpose (only if useful for a systematic review or synthesis)
William A. Nehmeh A* , Joseph Derienne A , Léa El Khoury B , Serge Kassar B , Viviane Trak-Smayra B , Roger Noun A , Ghassan Chakhtoura ADOI: 10.12659/AJCR.927094
Am J Case Rep 2021; 22:e927094
Figure 3. Photomicrographs showing histopathology and immunohistochemistry of the surgical resection specimen from a 58-year-old Lebanese woman who presented with acute gastric perforation due to metastatic ductal carcinoma 18 years following bilateral mastectomy. (A) Low-power image showing a cellular tumor replacing normal gastric mucosa and gastric wall. Hematoxylin and eosin (H&E); magnification ×10. (B) High-power image showing small cells with dark pink cytoplasm, arranged in small groups, consistent with the diagnosis of ductal carcinoma of the breast. H&E, magnification ×40. (C) Immunohistochemistry for human epidermal growth factor receptor 2 (HER2) showing that the tumor cells are HER2-negative. Magnification ×10. (D) Immunohistochemistry showing that the tumor cells are positive for cytokeratin 7 (CK7) (brown). Magnification ×10. (E) Immunohistochemistry showing that the tumor cells are positive for GATA3 (brown arrow). Magnification ×10. (F) Immunohistochemistry showing that the tumor cells are HER2-negative. Magnification ×10.