Figure 1. Magnetic resonance imaging (MRI), computed tomography (CT), histopathology, and immunohistochemistry in the diagnosis of a fulminant AFPGC in a 50-year-old man. (A) Brain MRI shows multiple ischemic lesions (red arrows). (B) CT imaging documents multiple and disseminated subcutaneous metastases (red arrows). (C) Computed tomography angiography (CTA) confirms a left popliteal artery thrombosis (red circle). (D) Abdominal CT imaging shows an infarction of the spleen (red circle). (E) Abdominal CT imaging shows a renal infarct (red circle). (F) Photomicrograph of the tumor histology reports pleomorphic malignant cells with ‘hepatoid’ appearance. Hematoxylin and eosin (H&E). Magnification ×10. (G) Photomicrograph of the immunohistochemistry for alpha-fetoprotein (AFP) shows focally positive staining of malignant cells. Magnification ×40. (H) Brain CT documents a massive intraventricular brain hemorrhage (red arrows).