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04 February 2021: Articles

Cyclophosphamide as a Treatment for Focal Segmental Glomerular Sclerosis Recurrence in a Kidney Transplant Patient

Unusual or unexpected effect of treatment

Mariann H. Al-Jehani E , Faisal Al-Husayni A , Abdullah Aljabri B , Hatim Qasim AlMaghraby B , Turki A. Banamah A*

DOI: 10.12659/AJCR.929097

Am J Case Rep 2021; 22:e929097

Figure 2. (A) In August 2016, an image representative of a glomerulus involvement by segmental sclerosis: segmental obliteration of a capillary loop segment with associated expansion of mesangial matrix by hyaline matrix, in a non-characteristic localization appearing red, PAS stain, ×400. A capsular adhesion of the corresponding segment is present. (B) In May 2019, the image demonstrates glomeruli involvement, in a non-characteristic localization, by segmental sclerosis and capsular adhesion, H&E stain, ×400. (C) In May 2019, the image demonstrates a corticomedullary glomerulus involvement by segmental sclerosis and capsular adhesion, H&E stain, ×400. (D) An electron microscopic image demonstrates effacement and fusion of podocyte foot processes over long segments (>90%) of the glomerular basement membranes, EM, ×2000.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923