15 April 2021>: Articles
Metastatic Mixed Adeno-Neuroendocrine Carcinoma of the Colon to the Liver with Multiple Peritoneal Deposits: A Case Report
Challenging differential diagnosis, Rare disease
Abdullah Saleh AlQattan A* , Najd Saad AlSulaiman A , Mohammed Yousef AlDossary A , Mohammed AlSomali A , Turki Alshammari ADOI: 10.12659/AJCR.929099
Am J Case Rep 2021; 22:e929099
Figure 3. Microscopic examination of the colonoscopic biopsy showing: (A) Section shows a large cell neuroendocrine carcinoma with organoid and rosette-like growth pattern (200× magnification; H&E). (B) Adenocarcinoma component as demonstrated by highly atypical structures (Red arrows) intermingled with neuroendocrine carcinoma (yellow arrows) (200×, H&E). (C) Synaptophysin immunohistochemical stain is diffusely positive in the neuroendocrine carcinoma component. (D) Synaptophysin immunohistochemical stained negative in adenocarcinoma component (400×). (E) Ki-67 proliferative index in neuroendocrine carcinoma is estimated at >90% (400×).