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19 January 2021: Articles

Follicular B-Cell Lymphoma and Particulate Matter Associated with Environmental Exposure to Wood Dust

Unusual clinical course, Challenging differential diagnosis, Educational Purpose (only if useful for a systematic review or synthesis)

Tiziano M. Scarabelli ** , Giovanni Corsetti * , Carol Chen-Scarabelli A , Louis D. Saravolatz A

DOI: 10.12659/AJCR.929396

Am J Case Rep 2021; 22:e929396

Figure 2. A pleural fluid sample. (A) A cluster of atypical lymphocytes. The cells have distinct nuclear bodies and a high nucleus-to-cytoplasm ratio. From these cells originates a net of filaments (filopodia-like filaments) that reach and trap surrounding cells (scale bar=50 µm). (B) A nanotube-like filament connects 2 atypical lymphocytes (arrow). Small particles of intensely-stained material are present in the cytoplasm as well as at the periphery of the nucleus and close to the cell membrane (scale bar=5 µm). (C) Densely-stained material similar to nuclear chromatin (white asterisk) is seen in the cytoplasm of atypical lymphocytes. The material gives rise to 2 thin tubes containing small particles of condensed material (short arrows), which probably were created when the main mass fragmented (scale bar=5 µm). (D, E) Unusually long, large-caliber cylindrical fibers (white arrows), many with truncated ends (asterisk in D), are seen in the pleural fluid. The black arrow points to the filopodia-like filaments (scale bar=10 µm).

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923