15 May 2021
: Case report 
A 25-Year-Old Man with Refractory Schizophrenia and Clozapine-Induced Myocarditis Diagnosed by Non-Invasive Cardiovascular Magnetic Resonance
Rare disease, Adverse events of drug therapy
Tiffany Brazile1BCDEF*, Amr F. Barakat2E, Syed Bukhari2E, Erik B. Schelbert2CD, Prem Soman2ACDEDOI: 10.12659/AJCR.930103
Am J Case Rep 2021; 22:e930103
Figure 2. Cardiovascular magnetic resonance (CMR) demonstrates myocardial changes that reveal the diagnosis. (A) Late gadolinium enhancement CMR revealed acute myocarditis as evidenced by epicardial necrosis and edema of the middle and apical lateral wall (yellow arrowheads), as well as small foci of mid-myocardial necrosis in the apical septum (red arrowheads). (B) Direct T2 quantification confirmed the presence of myocardial edema indicative of acute ischemia in these regions, measuring 84.5±6.3 ms (Region 1), compared with 61.9±4.7 ms in healthy non-ischemic myocardium (Region 2). These findings support the diagnosis of clozapine-induced myocarditis.