Giant Cell Tumor of Bone of the First Rib Successfully Treated with Combined Preoperative Denosumab Therapy and Surgery via a Transmanubrial Approach

Tomoya Matsunobu; Akira Maekawa; Akira Nabeshima; Akio Sakamoto; Kazuki Tamura; Seiichi Odate; Yukihide Iwamoto

doi:10.12659/AJCR.931796

01 June 2021 : Case report Japan

Giant Cell Tumor of Bone of the First Rib Successfully Treated with Combined Preoperative Denosumab Therapy and Surgery via a Transmanubrial Approach

Rare disease

Tomoya Matsunobu^1ABDEF*, Akira Maekawa^1BD, Akira Nabeshima^1B, Akio Sakamoto^2A, Kazuki Tamura^3AD, Seiichi Odate^4AD, Yukihide Iwamoto^1DE

DOI: 10.12659/AJCR.931796

Am J Case Rep 2021; 22:e931796

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Figure 4. Microscopic images of the tumor specimen prior to denosumab therapy (hematoxylin and eosin staining). The tumor demonstrates diffuse proliferation of multinucleated, osteoclast-like giant cells and uniform ovoid- to spindle-shaped mononuclear stromal cells.

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Giant Cell Tumor of Bone of the First Rib Successfully Treated with Combined Preoperative Denosumab Therapy and Surgery via a Transmanubrial Approach

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