01 June 2021>: Articles
Giant Cell Tumor of Bone of the First Rib Successfully Treated with Combined Preoperative Denosumab Therapy and Surgery via a Transmanubrial Approach
Rare disease
Tomoya Matsunobu A* , Akira Maekawa B , Akira Nabeshima B , Akio Sakamoto A , Kazuki Tamura A , Seiichi Odate A , Yukihide Iwamoto DDOI: 10.12659/AJCR.931796
Am J Case Rep 2021; 22:e931796
Figure 4. Microscopic images of the tumor specimen prior to denosumab therapy (hematoxylin and eosin staining). The tumor demonstrates diffuse proliferation of multinucleated, osteoclast-like giant cells and uniform ovoid- to spindle-shaped mononuclear stromal cells.