01 June 2021
: Case report 
Giant Cell Tumor of Bone of the First Rib Successfully Treated with Combined Preoperative Denosumab Therapy and Surgery via a Transmanubrial Approach
Rare disease
Tomoya Matsunobu1ABDEF*, Akira Maekawa1BD, Akira Nabeshima1B, Akio Sakamoto2A, Kazuki Tamura3AD, Seiichi Odate4AD, Yukihide Iwamoto1DEDOI: 10.12659/AJCR.931796
Am J Case Rep 2021; 22:e931796
Figure 6. (A) Skin incision (thin solid line), L-shaped sternal division (thick solid line), and release of the sternal head and the clavicular head of the sternocleidomastoid muscle from its origin (dashed line) are illustrated. (B) Gross specimen and pathological findings. The tumor in the first rib was resected. The tumor (arrow) was covered by smooth pleura. (C) A microscopic view shows diffuse proliferation of short, spindle-shaped cells without nuclear atypia, as well as osteoid formation and extensive fibrosis throughout the entire specimen. No giant cells are observed (hematoxylin and eosin staining).