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01 June 2021: Articles

Giant Cell Tumor of Bone of the First Rib Successfully Treated with Combined Preoperative Denosumab Therapy and Surgery via a Transmanubrial Approach

Rare disease

Tomoya Matsunobu A* , Akira Maekawa B , Akira Nabeshima B , Akio Sakamoto A , Kazuki Tamura A , Seiichi Odate A , Yukihide Iwamoto D

DOI: 10.12659/AJCR.931796

Am J Case Rep 2021; 22:e931796

Figure 6. (A) Skin incision (thin solid line), L-shaped sternal division (thick solid line), and release of the sternal head and the clavicular head of the sternocleidomastoid muscle from its origin (dashed line) are illustrated. (B) Gross specimen and pathological findings. The tumor in the first rib was resected. The tumor (arrow) was covered by smooth pleura. (C) A microscopic view shows diffuse proliferation of short, spindle-shaped cells without nuclear atypia, as well as osteoid formation and extensive fibrosis throughout the entire specimen. No giant cells are observed (hematoxylin and eosin staining).

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923