Figure 3. Core biopsy of breast lesion, showing small round-to-oval and short spindle-shaped cells arranged in sheets. These cells are characterized by high nuclear-to-cytoplasmic ratio, molded nuclei with salt-and-pepper chromatin, and no distinct nucleoli (A, B. Hematoxylin and eosin-stained sections, 200× and 400× total magnifications, respectively). High-grade malignancy is evidenced by frequent mitoses (C – highlighted by arrows) and areas of necrosis (D – highlighted by asterisk) – (C, D: Hematoxylin and eosin-stained sections, 400× total magnification).