25 August 2021>: Articles
Transition From Distinct Types of Mutation-Harboring Multifocal Lung Adenocarcinoma to Rhabdoid Tumor: A Longitudinal Follow-Up
Challenging differential diagnosis, Rare disease
Kensuke Setoguchi * , Shigehisa Yanagi ** , Toshihiro Gi A , Hironobu Tsubouchi A , Kazuko Uto A , Takafumi Shigekusa A , Nobuhiro Matsumoto A , Yuichiro Sato A , Masamitsu Nakazato ADOI: 10.12659/AJCR.932452
Am J Case Rep 2021; 22:e932452
Figure 2. Autopsy findings of the right lower lobe of the lung. (A) Gross appearance. The tumor was well- to partly ill-demarcated and irregularly shaped with massive hemorrhage (arrowhead). (B–E) Histological examination of the right S6 mass specimens revealed an extensive necrotic area (* in B) with a component of the solid area with rhabdoid cells, characterized by large cells with eccentrically located nuclei, prominent nucleoli, abundant eosinophilic cytoplasm, and large paranuclear intracytoplasmic inclusions († in B, C). The tumor also had a component of non-mucinous adenocarcinoma with focal intracytoplasmic mucin (‡ in B, D). (E) A continuum of changes from adenocarcinoma (‡) to the solid area with rhabdoid cells (†). B: 15×; C: 400×; D, E: 200× magnification. Hematoxylin and eosin (H&E) stain.