Transition From Distinct Types of KRAS Mutation-Harboring Multifocal Lung Adenocarcinoma to Rhabdoid Tumor: A Longitudinal Follow-Up

Kensuke Setoguchi; Shigehisa Yanagi; Toshihiro Gi; Hironobu Tsubouchi; Kazuko Uto; Takafumi Shigekusa; Nobuhiro Matsumoto; Yuichiro Sato; Masamitsu Nakazato

doi:10.12659/AJCR.932452

25 August 2021 : Case report Japan

Transition From Distinct Types of KRAS Mutation-Harboring Multifocal Lung Adenocarcinoma to Rhabdoid Tumor: A Longitudinal Follow-Up

Challenging differential diagnosis, Rare disease

Kensuke Setoguchi^1ABCDEF, Shigehisa Yanagi^1ABCDEFG*, Toshihiro Gi

^2ADE, Hironobu Tsubouchi^1AE, Kazuko Uto^1ABCDEF, Takafumi Shigekusa

^1ABE, Nobuhiro Matsumoto

^1AE, Yuichiro Sato^3AE, Masamitsu Nakazato^1AE

DOI: 10.12659/AJCR.932452

Am J Case Rep 2021; 22:e932452

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Figure 3. Immunohistochemical findings of the tumor in the right lobe of the lung. The adenocarcinoma component was positive for AE1/AE3 (A), CAM 5.2 (C), CK7 (F), and CK20 (G). Little immunopositivity for MUC5AC (H) and HNF4α (I) was observed in the adenocarcinoma lesion. The component of rhabdoid cells was positive for AE1/AE3 (B), CAM 5.2 (D), and vimentin (E). Paranuclear intracytoplasmic inclusions were strongly positive for vimentin in some of the rhabdoid cells (E, arrowheads). A–I: 200× magn.

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Transition From Distinct Types of KRAS Mutation-Harboring Multifocal Lung Adenocarcinoma to Rhabdoid Tumor: A Longitudinal Follow-Up

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