06 December 2021
: Case report 
Lipedema Can Be Treated Non-Surgically: A Report of 5 Cases
Unusual clinical course, Challenging differential diagnosis, Unusual setting of medical care, Educational Purpose (only if useful for a systematic review or synthesis)
Alexandre Campos Moraes Amato
12ABCDEF*, Daniel Augusto Benitti3BE
DOI: 10.12659/AJCR.934406
Am J Case Rep 2021; 22:e934406
Figure 1. Classification of lipedema by evolutionary stages [21]. Stage 1: normal skin with an enlarged hypodermis; Stage 2: unevenness of the skin texture with pleats of fat and large piles of tissue growing like unencapsulated masses; Stage 3: hardening and thickening of the subcutaneous with large nodules and protrusion of cushions/accumulations of fat, especially in the thighs and around the knees; Stage 4: lipedema with lymphedema, so-called lipolymphedema.