An 81-Year-Old Man with a 6-Year History of Chronic Lymphocytic Leukemia Presenting with Disease Flare Following Ibrutinib Discontinuation

Stefano Pozzi; Leonardo Potenza; Davide Giusti; Elisabetta Colaci; Valeria Pioli; Giovanna Leonardi; Monica Maccaferri; Mario Luppi; Roberto Marasca

doi:10.12659/AJCR.935941

26 August 2022 : Case report Italy

An 81-Year-Old Man with a 6-Year History of Chronic Lymphocytic Leukemia Presenting with Disease Flare Following Ibrutinib Discontinuation

Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment

Stefano Pozzi^1EF*, Leonardo Potenza^12AE, Davide Giusti

^1AE, Elisabetta Colaci^1AE, Valeria Pioli^1AE, Giovanna Leonardi^1DE, Monica Maccaferri^1D, Mario Luppi^12ABCDEFG, Roberto Marasca^12ABCDEFG

DOI: 10.12659/AJCR.935941

Am J Case Rep 2022; 23:e935941

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Figure 1. Hematoxylin & eosin-stained peripheral blood film showing the characteristically small, mature lymphocytes with a narrow border of cytoplasm and a dense nucleus lacking discernible nucleoli and having partially aggregated chromatin and Gumprecht nuclear shadows.

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An 81-Year-Old Man with a 6-Year History of Chronic Lymphocytic Leukemia Presenting with Disease Flare Following Ibrutinib Discontinuation

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