Giant-Cell Aortitis-Induced Acute Aortic Insufficiency: An Underestimated Etiology

Muhammad Atif Masood Noori; Mahsa Mohammadian; Hasham Saeed; Jesus Romero; Jesani Shruti; Hardik Fichadiya; Sherif Elkattawy; Qirat Jawed; Dhaval Shah; Kalpesh K. Shah; Ioannis Loumiotis; Meherwan B. Joshi; Bille Fyfe

doi:10.12659/AJCR.937836

22 June 2023 : Case report USA

Giant-Cell Aortitis-Induced Acute Aortic Insufficiency: An Underestimated Etiology

Challenging differential diagnosis, Rare coexistence of disease or pathology

Muhammad Atif Masood Noori^1AE*, Mahsa Mohammadian^1F, Hasham Saeed^1EF, Jesus Romero^1E, Jesani Shruti^1E, Hardik Fichadiya^1E, Sherif Elkattawy^1E, Qirat Jawed^1E, Dhaval Shah^2F, Kalpesh K. Shah^2E, Ioannis Loumiotis^3DEF, Meherwan B. Joshi^1DEF, Bille Fyfe^4E

DOI: 10.12659/AJCR.937836

Am J Case Rep 2023; 24:e937836

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Figure 4. Low-power view of the aortic wall (intima on bottom, adventitia on top) with areas of medial necrosis (arrows) surrounded by dense inflammation (H&E 40×) (A). Medium-power view of areas of medial necrosis (arrow) with surrounding lymphocytic and histiocytic inflammation. Inset demonstrates a multinucleated giant cell (circle) (H&E 100×, inset H&E 200×) (B). Elastic stain of aortic wall highlighting compressed elastic lamellae in areas of necrosis (arrows) with surrounding pallor due to loss of elastic tissue related to dense inflammation (Elastic Van Gieson stain 40×) (C).

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Giant-Cell Aortitis-Induced Acute Aortic Insufficiency: An Underestimated Etiology

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