Figure 18. Case 6: (A) A parotid biopsy shows melanoma present as loosely clustered malignant cells with nuclear hyperchromasia and amphophilic cytoplasm (hematoxylin and eosin [H&E], original magnification ×200). (B) Subsequent parotid resection demonstrates metastatic melanoma (upper right portion of image) involving an intraparotid lymph node (H&E, ×200). (C) A lung biopsy shows metastatic melanoma with similar morphologic features (H&E, ×200) and (D) diffuse SOX10 reactivity (immunohistochemistry, ×200). (E) The subsequent lung wedge resection specimen demonstrates extensive treatment effect with sheets of melanophages without histologically viable tumor cells (H&E ×200). (F) A special stain for melanin highlights these melanin-containing histiocytes (Fontana Masson, ×200).