04 February 2023
: Case report 
Malignant Melanoma Arising from Esophageal Melanosis and Synchronous with Esophageal Squamous Cell Carcinoma
Rare disease
Yoshihiro Ota1E*, Kenichi Iwasaki1B, Kenta Miyoshi1B, Masaya Enomoto1B, Tesshi Yamada1G, Yuichi Nagakawa1ADOI: 10.12659/AJCR.938617
Am J Case Rep 2023; 24:e938617
Figure 4. (A) Tumor cells with nucleoli and swelling anisocytosis of different sizes densely proliferating in sheet-like and large-sized follicle-like forms. The lesion was accompanied by the deposition of melanin pigment. Cellular proliferation of melanocytes was observed on the intraepithelial basal side of the melanoma around the tumor, but no development of malignant melanoma was observed (hematoxylin and eosin, ×20). (B) Immunohistochemical staining for MelanA was positive (×200). (C) Immunohistochemical staining for HMB45 was positive (×200). (D) Immunohistochemical staining for S100 was positive (×200).