Figure 2. (A, F) Histology of primary and liver metastasis of solid pseudopapillary neoplasm of the pancreas on hematoxylin and eosin (H&E) staining. The photomicrographs show monomorphic epithelial cells with vacuolated cytoplasm in solid sheets. (B–E, G–J) Immunohistochemical staining demonstrates the characteristic profile of solid pseudopapillary neoplasm of the pancreas: beta-catenin (B-cat: nuclear and cytoplasmic positivity), vimentin (Vim: positive), cytokeratins (CK18, CK5: negative), synaptophysin (Syp: negative). Text colors correspond to the staining chromogens. Yellow dotted area (F, G, I, J) indicates atrophic peritumoral hepatocytes. Green arrows (B, G) indicate beta-catenin+tumor cell nuclei.