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08 March 2023: Articles

Plasma Cell Leukemia with Successful Upfront Venetoclax in Combination with Allogeneic Transplantation

Challenging differential diagnosis, Unusual setting of medical care, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)

Andy Sing Ong Tang A , Asral Wirda Ahmad Asnawi A* , Alex Zhi Yang Koh A , Siew Lian Chong A , Pek Kuen Liew B , Veena Selvaratnam A , Alina Md Fauzi E , Ngee Siang Lau D , Sen Mui Tan A

DOI: 10.12659/AJCR.938868

Am J Case Rep 2023; 24:e938868

Figure 1. Morphological features of plasma cell leukemia. (A) The peripheral blood film shows lymphoplasmacytic cells and background rouleaux. (Wrights-Giemsa stain at 60× magnification). (B) The bone marrow aspiration is markedly hypercellular with increase in plasma cells. (May-Grunwald Giemsa stain at 20× magnification). (C, D) The trephine biopsy showed suppression of trilineage hematopoiesis and infiltration by neoplastic plasma cells, which have eccentric nucleus, chromatin arranged in a cog-wheel pattern and abundant basophilic-to-pinkish cytoplasm. (H&E stain at 20× and 60× magnification). (E) The neoplastic plasma cells are CD138-positive. (F) CD117-negative. (G) Lambda-light-chain-restricted. (H) Kappa light chain-negative. (I) Cyclin D1-positive. (J) CD56-negative. (Immunohistochemistry stain at 4× magnification)

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923