16 May 2023>: Articles
Clinically Aggressive Uterine Epithelioid Leiomyosarcoma with Rhabdomyoblastic Differentiation and High Proliferation Rate: A Case Report
Challenging differential diagnosis, Unusual setting of medical care, Rare diseaseJi Yeon Kim D , Bomi Kim A*
Am J Case Rep 2023; 24:e939349
Figure 2. Microscopic findings. (A) On low-power magnification, spindle cells are focally arranged in interlacing bundles (hematoxylin and eosin, ×100). (B) Intravascular invasion and lymphovascular tumor emboli are observed (hematoxylin and eosin, ×100). (C) Rhabdoid cells, which have central eosinophilic inclusions and large eccentric nuclei with prominent nucleoli, are admixed with epithelioid cells (hematoxylin and eosin, ×400). (D) Elongated cells with abundant eosinophilic cytoplasm, called strap cells, seldom appear (hematoxylin and eosin, ×400). (E) Atypical mitosis is noted among spindle cells (hematoxylin and eosin, ×400). (F) Epithelioid and rhabdoid cells are focally immunoreactive for myogenin antibodies (myogenin immunohistochemistry, ×100). (G) Desmin is expressed in epithelioid and rhabdoid cells but not in spindle cells (desmin immunohistochemistry, ×200). (H) The cytoplasm of rhabdoid cells react with antibodies against smooth muscle actin (smooth muscle actin immunohistochemistry ×200).