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21 March 2023: Articles

Perioperative Management of Recurrent Hemophagocytic Syndrome in a Pregnant Woman: A Case Report

Challenging differential diagnosis, Management of emergency care, Patient complains / malpractice, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)

Ayako Sumii A , Hirotsugu Miyoshi A* , Takahiro Kato B , Sachiko Otsuki A , Yousuke T. Horikawa A , Shiho Satomi A , Noboru Saeki B , Yusuke Yoshida E , Yasuo M. Tsutsumi A

DOI: 10.12659/AJCR.939369

Am J Case Rep 2023; 24:e939369

Figure 1. Patient presentation and treatment course during the first pregnancy. At 28 weeks of gestation, HPS was diagnosed, and steroid therapy was initiated. Hepatic dysfunction improved, but serum ferritin did not decrease, platelet count dropped, and fever persisted. To prevent maternal complications, premature delivery of the fetus and a cesarean section were performed at 29 weeks. However, after delivery, HPS did not improve, and immunochemotherapy with dexamethasone, etoposide, and cyclosporine was started on the fourth postoperative day. After the start of chemotherapy, the patient’s fever gradually resolved, and her platelet count increased. The patient was discharged from the hospital after her platelet count normalized 1 month following delivery. Ferritin was normalized 2 months after surgery, and chemotherapy was completed 6 months after delivery.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923