A Rare Case of Non-IgM Lymphoplasmacytic Lymphoma with Unusual Lack of Immunoglobulin Light Chain Production

Jiejing Yin; Ashish Bains; Mohamed Alsammak; Jian Jeff Fu

doi:10.12659/AJCR.940963

04 March 2024 : Case report USA

A Rare Case of Non-IgM Lymphoplasmacytic Lymphoma with Unusual Lack of Immunoglobulin Light Chain Production

Challenging differential diagnosis, Rare disease

Jiejing Yin^1CE, Ashish Bains

^1CDE, Mohamed Alsammak^1E, Jian Jeff Fu^1ABCDEF*

DOI: 10.12659/AJCR.940963

Am J Case Rep 2024; 25:e940963

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Figure 4. Bone marrow showing involvement by lymphoplasmacytic lymphoma. In situ hybridization for kappa (A) and lambda (B) demonstrating lack of light chain expression by neoplastic infiltrate. Immunohistochemistry highlighting the neoplastic plasma cell that express IgA (C), while lacking IgM (D).

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A Rare Case of Non-IgM Lymphoplasmacytic Lymphoma with Unusual Lack of Immunoglobulin Light Chain Production

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