Rare Case of Recurrent Adamantinoma of the Tibia: Limited Efficacy of Pazopanib as a Standalone Treatment

Mahmoud Elshenawy; Sarah Khaled Aldahoul; Abduljalil Mohamed El-Sibai; Alaa Hamad; Tarek Ziad Arabi; Saleha Abdul Rab; Ahmed Badran; Tariq Alzaid; Belal Nedal Sabbah; Jean Paul Atallah

doi:10.12659/AJCR.941248

15 March 2024: Articles

Rare Case of Recurrent Adamantinoma of the Tibia: Limited Efficacy of Pazopanib as a Standalone Treatment

Unusual or unexpected effect of treatment, Rare disease

Mahmoud Elshenawy ^A , Sarah Khaled Aldahoul ^E , Abduljalil Mohamed El-Sibai ^E , Alaa Hamad ^E , Tarek Ziad Arabi ^A* , Saleha Abdul Rab ^E , Ahmed Badran ^A , Tariq Alzaid ^D , Belal Nedal Sabbah ^E , Jean Paul Atallah ^A

DOI: 10.12659/AJCR.941248

Am J Case Rep 2024; 25:e941248

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Figure 3. (A) Hematoxylin and eosin-stained section showing atypical spindle to epithelioid cell proliferation (black arrow) with fibrotic stroma (red arrow), consistent with adamantinoma. Immunostaining for cytokeratins 5/6 (B) and p63 (C) showing positive staining in tumor cells.

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Rare Case of Recurrent Adamantinoma of the Tibia: Limited Efficacy of Pazopanib as a Standalone Treatment

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