Rare Case of Recurrent Adamantinoma of the Tibia: Limited Efficacy of Pazopanib as a Standalone Treatment

Mahmoud Elshenawy; Sarah Khaled Aldahoul; Abduljalil Mohamed El-Sibai; Alaa Hamad; Tarek Ziad Arabi; Saleha Abdul Rab; Ahmed Badran; Tariq Alzaid; Belal Nedal Sabbah; Jean Paul Atallah

doi:10.12659/AJCR.941248

15 March 2024 : Case report Saudi Arabia

Rare Case of Recurrent Adamantinoma of the Tibia: Limited Efficacy of Pazopanib as a Standalone Treatment

Unusual or unexpected effect of treatment, Rare disease

Mahmoud Elshenawy^12ADE, Sarah Khaled Aldahoul^3EF, Abduljalil Mohamed El-Sibai^3EF, Alaa Hamad^3EF, Tarek Ziad Arabi^3ADEF*, Saleha Abdul Rab^3EF, Ahmed Badran^45ADE, Tariq Alzaid^6DE, Belal Nedal Sabbah^3E, Jean Paul Atallah^4ADE

DOI: 10.12659/AJCR.941248

Am J Case Rep 2024; 25:e941248

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Figure 3. (A) Hematoxylin and eosin-stained section showing atypical spindle to epithelioid cell proliferation (black arrow) with fibrotic stroma (red arrow), consistent with adamantinoma. Immunostaining for cytokeratins 5/6 (B) and p63 (C) showing positive staining in tumor cells.

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Rare Case of Recurrent Adamantinoma of the Tibia: Limited Efficacy of Pazopanib as a Standalone Treatment

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