04 December 2023 : Case report
A Case Report of a Rare ER+, PR- Pure Metaplastic Breast Squamous Cell Carcinoma with HER2 Overexpression
Challenging differential diagnosis, Unusual or unexpected effect of treatment, Rare disease
Shafawati Akmal Adam1ABCDEF, Khairatul Nainey Kamaruddin1E, Nordashima Abd Shukor2BCDEF, Shahrun Niza Abdullah Suhaimi3CDE, Fuad Ismail4CDE, Mazapuspavina Md Yasin 1ABCDEF*DOI: 10.12659/AJCR.941448
Am J Case Rep 2023; 24:e941448
Figure 3. (A) Right breast mammogram. (B) Ultrasound of the right breast. (C) Ultrasound of the right axillary lymph node. (A) Right breast mammogram showing heterogenous fibro glandular density. The Breast imaging reporting and data system (BIRADS) level was C, showing a large mass at the right upper quadrant. Multiple smaller high-density lesions in the right upper quadrant of the breast are visible. An area of hyperdensity over the right breast, upper quadrant, is visible. The red arrows show a dense, microlobulated cystic mass (these are typical mammography findings prompting suspicion of breast cancer). There is an associated right breast diffuse opacity due to edema. No suspicious grouped microcalcifications were seen. (B) Large thick-walled lobulated cystic mass with septations occupying the right upper quadrant, measuring 2.7×3.4×3.4 cm. There was a linear hypoechogenicity across the anterior aspect of the lesion in keeping with the previous wound. Several ill-defined hypoechoic lesions at the medial aspect of the above-mentioned lesions were visible. They were increased in size and number compared with recent sonograms, at the 12 o’clock and 1 o’clock positions; ranging from 0.7 cm to 2.3 cm. The overlying skin appeared to be thickened. (C) Enlarged right axillary node with cystic area measuring 1.2 cm in short axis diameter.