Adjunctive Intravenous Immunoglobulin and Glucocorticoid Therapy in Severe Herpes Simplex Encephalitis with Excellent Outcome Begs for Larger Trials Evaluating Immunomodulatory Therapy

George Sakoulas; Jon Roth; Hugo Van der Kuy

doi:10.12659/AJCR.941864

14 January 2024 : Case report USA

Adjunctive Intravenous Immunoglobulin and Glucocorticoid Therapy in Severe Herpes Simplex Encephalitis with Excellent Outcome Begs for Larger Trials Evaluating Immunomodulatory Therapy

Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Clinical situation which can not be reproduced for ethical reasons

George Sakoulas^12ABDEF*, Jon Roth^3ABE, Hugo Van der Kuy

^4BCE

DOI: 10.12659/AJCR.941864

Am J Case Rep 2024; 25:e941864

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Figure 1. Brain MRI of a 21-year-old man with severe HSV-1 encephalitis showing bilateral, primarily cortically based, asymmetric edema with underlying restricted diffusion involving the frontal lobes, insula, and temporal lobes, right greater than left, with relative sparing of the basal ganglia. Arrows point to some areas of involvement. MRI, magnetic resonance imaging; HSV-1, herpes simplex virus 1.

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Adjunctive Intravenous Immunoglobulin and Glucocorticoid Therapy in Severe Herpes Simplex Encephalitis with Excellent Outcome Begs for Larger Trials Evaluating Immunomodulatory Therapy

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