07 November 2023
: Case report 
Neoadjuvant Lorlatinib Induces Pathological Complete Response in Advanced ALK-Positive Lung Cancer: A Case Report
Unusual or unexpected effect of treatment, Unexpected drug reaction
Jie Li1E, Junwei Liu2BC, Guqin Zhang3B, Weidong Hu2G, Xianguo Wang2B*, Jun Liu2ADOI: 10.12659/AJCR.942150
Am J Case Rep 2023; 24:e942150
Figure 2. Timeline of CT examinations before surgery. (A) On the first CT before therapy, a solid nodule was found in the right upper lobe, measuring approximately 10×9 mm, with irregular margins. Enlarged R10 and L4 lymph nodes were also found in the mediastinum. (B) One month after neoadjuvant therapies, CT showed decreased size of the nodule beneath the pleura (from 10×9 mm to 5×4 mm) and reduced size of R10 and L4 lymph nodes. (C) Two months after neoadjuvant therapies but before surgery, CT showed the nodule beneath the pleura had remained the same size (5×4 mm) and the lymph node had decreased in size (from 28×18 mm to 17×16 mm).