29 December 2023 : Case report
Germline BRCA2 Pathogenic Variant in Primary Breast Cancer of a Down Syndrome Individual
Rare coexistence of disease or pathology
Tsuyoshi Shinohara 1ABEF*, Takuo Asoda1A, Yuta Nakano1A, Hiroyuki Yamada1A, Yoshiro Fujimori1ADOI: 10.12659/AJCR.942208
Am J Case Rep 2023; 24:e942208
Figure 2. Histopathological findings. (A) Macroscopic image; (B) hematoxylin and eosin staining ×40; (C) hematoxylin and eosin staining ×40; (D) estrogen receptor staining; (E) progesterone receptor staining. (A) Macroscopically, the tumor was a well-defined, solid mass measuring 2.5×2.2 cm in size (black arrows) with wide extension in the direction of the left papillary side (white arrow). Microscopic findings revealing (B) invasive ductal carcinoma with (C) wide intraductal spreading. The tumor cells are strongly positive for (D) estrogen receptors and (E) almost negative for progesterone receptors.