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29 December 2023 : Case report  Japan

Germline BRCA2 Pathogenic Variant in Primary Breast Cancer of a Down Syndrome Individual

Rare coexistence of disease or pathology

Tsuyoshi Shinohara ORCID logo1ABEF*, Takuo Asoda1A, Yuta Nakano1A, Hiroyuki Yamada1A, Yoshiro Fujimori1A

DOI: 10.12659/AJCR.942208

Am J Case Rep 2023; 24:e942208

Figure 2. Histopathological findings. (A) Macroscopic image; (B) hematoxylin and eosin staining ×40; (C) hematoxylin and eosin staining ×40; (D) estrogen receptor staining; (E) progesterone receptor staining. (A) Macroscopically, the tumor was a well-defined, solid mass measuring 2.5×2.2 cm in size (black arrows) with wide extension in the direction of the left papillary side (white arrow). Microscopic findings revealing (B) invasive ductal carcinoma with (C) wide intraductal spreading. The tumor cells are strongly positive for (D) estrogen receptors and (E) almost negative for progesterone receptors.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923