Figure 6. Representative images of case 4. (A, B) Sites of alveolar bone exposure around the mandibular implants that triggered the medication-related osteonecrosis of the jaw (MRONJ; arrows). (C) Panoramic view of osteonecrosis in the alveolar region (upper arrows) and at the base of the mandible (lower arrows). (D, E) Computed tomography (CT) scan showing osteonecrosis in the mandibular symphysis (arrows); (F) H&E-stained sections showing inflammatory infiltrate from mandibular bone sequestration; 400× magnification (arrows); (G) 6-month and (H) 3-year follow-up CT scan showing bone repair in the mandibular symphysis (arrows). (I) Four-year follow-up panoramic view of bone repair in the alveolar region (left arrow) and at the base of the mandible (right arrow). (J) New alveolar bone exposure due to MRONJ relapse caused by prosthetic trauma (arrow). (K) Bone sequestration removed from the relapsed region. (L) One-year follow-up CT scan showing bone repair in the relapsed region (arrow).