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01 June 2024 : Case report  Japan

Simultaneous Acquisition of T790M Mutation and SCLC Transformation during Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma: A Rare Case Report

Unusual clinical course

Tatsuya Yazaki12AEF*, Masanobu Kimoto1E, Ayumi Minagawa1E, Takashi Maruno1E, Miwa Yamanaka12E, Kei Sonehara2EF, Mineyuki Hama1E, Toshitsugu Nakamura3E, Shintaro Kanda4E, Masayuki Hanaoka2E, Tsutomu Hachiya1EF

DOI: 10.12659/AJCR.943466

Am J Case Rep 2024; 25:e943466

Figure 1. Clinical course and series of treatments. (A) March 2012: Chest computed tomography (CT) showing a mass of 55×40 mm in the right lower lobe (yellow circle and arrowhead). (B) February 2015: Positron emission tomography (PET) showing an accumulation in the right chest wall. (C) March 2019: PET showed an accumulation in the right 6th and 7th ribs (yellow circle). Then, chest wall tumor resection was performed. (D) February 2020: PET showing an accumulation in the right chest wall, and head magnetic resonance imaging (MRI) showing a high-signal nodule of 15×10 mm on T1 in the left occipital lobe (yellow circle and arrowhead). (E) June 2021: Chest CT showing a nodule of 15×10 mm in the left lower lobe (yellow circle). (F) August 2021: Cerebrospinal fluid analysis shows that the individual cells have irregularly round, swollen nuclei with distinct nucleoli and mitosis.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923