01 June 2024
: Case report
Simultaneous Acquisition of T790M Mutation and SCLC Transformation during Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma: A Rare Case Report
Unusual clinical course
Tatsuya Yazaki12AEF*, Masanobu Kimoto1E, Ayumi Minagawa1E, Takashi Maruno1E, Miwa Yamanaka12E, Kei Sonehara2EF, Mineyuki Hama1E, Toshitsugu Nakamura3E, Shintaro Kanda4E, Masayuki Hanaoka2E, Tsutomu Hachiya1EFDOI: 10.12659/AJCR.943466
Am J Case Rep 2024; 25:e943466
Figure 3. Transition of tumor markers after transformation to small cell lung carcinoma. Neuro-specific enolase (NSE) was within the normal range at the time of combined small cell lung carcinoma diagnosis but increased with subsequent disease progression. Alterations in NSE were associated with disease progression in patients after initiating chemotherapy.