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01 June 2024 : Case report  Japan

Simultaneous Acquisition of T790M Mutation and SCLC Transformation during Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma: A Rare Case Report

Unusual clinical course

Tatsuya Yazaki12AEF*, Masanobu Kimoto1E, Ayumi Minagawa1E, Takashi Maruno1E, Miwa Yamanaka12E, Kei Sonehara2EF, Mineyuki Hama1E, Toshitsugu Nakamura3E, Shintaro Kanda4E, Masayuki Hanaoka2E, Tsutomu Hachiya1EF

DOI: 10.12659/AJCR.943466

Am J Case Rep 2024; 25:e943466

Figure 3. Transition of tumor markers after transformation to small cell lung carcinoma. Neuro-specific enolase (NSE) was within the normal range at the time of combined small cell lung carcinoma diagnosis but increased with subsequent disease progression. Alterations in NSE were associated with disease progression in patients after initiating chemotherapy.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923