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11 August 2024 : Case report  United Kingdom

Triple-Negative Pleomorphic Lobular Carcinoma in a BRCA1 Mutation Carrier: A Case of Complete Pathological Response

Rare coexistence of disease or pathology

Maheshika Jinadasa1BDEF, Alex Humphreys2BDEF, Eleanore J. Massey3BDE, Patricia Vergani1BDE, Makaela Jacob-Pearson4BDE, Katherine Smith4BDE, Sarah Vinnicombe ORCID logo5BDE, Thomas Papathomas ORCID logo67ABDEF*

DOI: 10.12659/AJCR.943882

Am J Case Rep 2024; 25:e943882

Figure 2. MRI breast with (A) T2 weighted and (B) post-contrast fat-suppressed images before neoadjuvant chemotherapy demonstrate an 82×63 mm lobulated complex mass with hyperintense central cystic components, with peritumoral and prepectoral edema. The peripherally enhanced solid components exhibited restricted diffusion and type II enhancement curves. MRI breast with contrast showing marked response upon neoadjuvant chemotherapy with a residual thick-walled cystic mass measuring 29×22 mm on T2 weighted imaging (C) and gradual rim enhancement (with a type 1b curve) (D); Complete pathological response highlighting non-viable peripheral (E) and central (F) tumoral areas, the former with a peripheral rim of histiocytes.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923