11 August 2024
: Case report
Triple-Negative Pleomorphic Lobular Carcinoma in a BRCA1 Mutation Carrier: A Case of Complete Pathological Response
Rare coexistence of disease or pathology
Maheshika Jinadasa1BDEF, Alex Humphreys2BDEF, Eleanore J. Massey3BDE, Patricia Vergani1BDE, Makaela Jacob-Pearson4BDE, Katherine Smith4BDE, Sarah VinnicombeDOI: 10.12659/AJCR.943882
Am J Case Rep 2024; 25:e943882
Figure 2. MRI breast with (A) T2 weighted and (B) post-contrast fat-suppressed images before neoadjuvant chemotherapy demonstrate an 82×63 mm lobulated complex mass with hyperintense central cystic components, with peritumoral and prepectoral edema. The peripherally enhanced solid components exhibited restricted diffusion and type II enhancement curves. MRI breast with contrast showing marked response upon neoadjuvant chemotherapy with a residual thick-walled cystic mass measuring 29×22 mm on T2 weighted imaging (C) and gradual rim enhancement (with a type 1b curve) (D); Complete pathological response highlighting non-viable peripheral (E) and central (F) tumoral areas, the former with a peripheral rim of histiocytes.






