Orbital Metastasis as the First Manifestation of Hepatocellular Carcinoma, and Its Effective Treatment with Combined Dual Immunotherapy: A Case Report and Review of the Literature

Jirapat Wonglhow; Arunee Dechaphunkul; Patrapim Sunpaweravong; Chirawadee Sathitruangsak; Suchaya Pajareeyaphan; Panu Wetwittayakhlang

doi:10.12659/AJCR.944002

03 June 2024 : Case report Thailand

Orbital Metastasis as the First Manifestation of Hepatocellular Carcinoma, and Its Effective Treatment with Combined Dual Immunotherapy: A Case Report and Review of the Literature

Unusual clinical course, Unusual setting of medical care

Jirapat Wonglhow

^1ABCDEF, Arunee Dechaphunkul^1BE, Patrapim Sunpaweravong^1BE, Chirawadee Sathitruangsak

^1BE, Suchaya Pajareeyaphan^2BE, Panu Wetwittayakhlang

^3ACDEF*

DOI: 10.12659/AJCR.944002

Am J Case Rep 2024; 25:e944002

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Figure 1. Right eye proptosis. (A, B) Right eye proptosis after incisional biopsy of the extraconal mass in the right eye and temporary tarsorrhaphy before systemic therapy and palliative radiotherapy. (C, D) Right eye proptosis improved after the first cycle of the STRIDE regimen (durvalumab plus tremelimumab) and palliative radiotherapy in the right orbit. (E, F) Right eye proptosis continued to improve after the sixth cycle of durvalumab.

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Orbital Metastasis as the First Manifestation of Hepatocellular Carcinoma, and Its Effective Treatment with Combined Dual Immunotherapy: A Case Report and Review of the Literature

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