Orbital Metastasis as the First Manifestation of Hepatocellular Carcinoma, and Its Effective Treatment with Combined Dual Immunotherapy: A Case Report and Review of the Literature

Jirapat Wonglhow; Arunee Dechaphunkul; Patrapim Sunpaweravong; Chirawadee Sathitruangsak; Suchaya Pajareeyaphan; Panu Wetwittayakhlang

doi:10.12659/AJCR.944002

03 June 2024 : Case report Thailand

Orbital Metastasis as the First Manifestation of Hepatocellular Carcinoma, and Its Effective Treatment with Combined Dual Immunotherapy: A Case Report and Review of the Literature

Unusual clinical course, Unusual setting of medical care

Jirapat Wonglhow

^1ABCDEF, Arunee Dechaphunkul^1BE, Patrapim Sunpaweravong^1BE, Chirawadee Sathitruangsak

^1BE, Suchaya Pajareeyaphan^2BE, Panu Wetwittayakhlang

^3ACDEF*

DOI: 10.12659/AJCR.944002

Am J Case Rep 2024; 25:e944002

Authors information Article notes Copyright and License information

Introduction Case Report Discussion Conclusions References:

Related articles Order reprints Share article Share by email

View HTML version

Figure 3. Right orbital mass pathology. (A) Histological examination revealed a tumor showing a trabecular, pseudoglandular, and solid pattern. The cytological features included atypical hepatocytes with mild pleomorphic nuclei, high nucleus-to-cytoplasm ratio, irregular nuclear membrane, prominent nucleoli, eosinophilic cytoplasm, and few mitotic figures. (B) Immunohistochemistry staining is positive for glypican-3. (C) Immunohistochemistry staining is positive for hepar-1.

Back to the Article

Orbital Metastasis as the First Manifestation of Hepatocellular Carcinoma, and Its Effective Treatment with Combined Dual Immunotherapy: A Case Report and Review of the Literature

Your Privacy